[3] Deportes Tolima 3-1 Deportes Quindio [16] 2021-11-21 20:30
Stadium: Estadio Manuel Murillo Toro Round: 20
Referee: Jorge Andres Tabares Cano Home Manager: Hernan Torres Away Manager: Oscar Hector Quintabani Faggionali
Head to Head
| Colombia - Cup | 2017/04/27 20:30 | Deportes Quindio v Deportes Tolima | W | 1-3 |
| Colombia - Cup | 2017/03/15 20:30 | Deportes Tolima v Deportes Quindio | D | 2-2 |
| Colombia - Cup | 2016/04/20 20:00 | Deportes Tolima v Deportes Quindio | W | 4-1 |
| Colombia - Cup | 2016/03/09 20:00 | Deportes Quindio v Deportes Tolima | L | 3-2 |
| Colombia - Cup | 2015/04/15 20:30 | Deportes Tolima v Deportes Quindio | D | 1-1 |
| Colombia - Cup | 2015/03/19 20:00 | Deportes Quindio v Deportes Tolima | L | 2-1 |
| Colombia - Cup | 2014/08/27 20:00 | Deportes Quindio v Deportes Tolima | W | 1-3 |
| Colombia - Cup | 2014/07/23 20:30 | Deportes Tolima v Deportes Quindio | W | 4-2 |