[14] Santos Laguna 0-1 Club America [5] 2017-11-20 00:30
Väder: Bra Stadium: Estadio TSM Corona Plan: Bra Round: 17
Referee: Diego Montano Robles Home Manager: Robert Siboldi Away Manager: Miguel Herrera
Head to Head
| Europa - Vänskapsmatcher | 2017/07/06 01:30 | Club America v Santos Laguna | L | 3-2 |
| Mexiko - Liga MX | 2017/04/24 00:00 | Santos Laguna v Club America | W | 2-1 |
| Mexiko - Cup | 2017/03/02 02:30 | Santos Laguna v Club America | W | 2-1 |
| Mexiko - Cup | 2017/01/19 02:30 | Club America v Santos Laguna | L | 3-2 |
| Mexiko - Liga MX | 2016/10/30 02:00 | Club America v Santos Laguna | L | 3-1 |
| CONCACAF Champions Cup | 2016/04/06 02:00 | Club America v Santos Laguna | L | 1-0 |
| CONCACAF Champions Cup | 2016/03/17 02:00 | Santos Laguna v Club America | D | 0-0 |
| Mexiko - Liga MX | 2016/02/06 23:00 | Club America v Santos Laguna | L | 2-0 |
| Mexiko - Liga MX | 2015/08/15 02:30 | Santos Laguna v Club America | L | 0-2 |
| Mexiko - Liga MX | 2015/03/14 23:00 | Club America v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2014/09/27 02:30 | Santos Laguna v Club America | L | 1-4 |
| Mexiko - Liga MX | 2014/05/04 02:00 | Santos Laguna v Club America | W | 3-1 |
| Mexiko - Liga MX | 2014/05/01 01:00 | Club America v Santos Laguna | L | 5-3 |