[4] Spartak Moskva 3-3 Villarreal [2] 2018-10-04 19:00
Stadium: Otkritie Arena Round: 2
Referee: Daniel Siebert Home Manager: Massimo Carrera Away Manager: Javier Calleja Revilla
Home History
| Ryssland - Premier League | 2018/09/30 16:00 | Spartak Moskva v Rostov | L | 0-1 |
| Ryssland - Cup | 2018/09/26 15:30 | FK Chernomorets Novorossiysk v Spartak Moskva | W | 0-1 |
| Ryssland - Premier League | 2018/09/23 16:00 | CSKA Moskva v Spartak Moskva | D | 1-1 |
| UEFA Europa League | 2018/09/20 16:55 | Rapid Wien v Spartak Moskva | L | 2-0 |
| Ryssland - Premier League | 2018/09/16 16:00 | Spartak Moskva v FC Akhmat Grozny | L | 1-2 |
| Ryssland - Premier League | 2018/09/02 16:00 | Zenit St Petersburg v Spartak Moskva | D | 0-0 |
| Ryssland - Premier League | 2018/08/25 16:00 | Spartak Moskva v Dynamo Moskva | W | 2-1 |
| Ryssland - Premier League | 2018/08/18 16:00 | Krasnodar v Spartak Moskva | W | 0-1 |
Away History
| Spanien - La Liga | 2018/09/30 14:15 | Villarreal v Valladolid | L | 0-1 |
| Spanien - La Liga | 2018/09/26 18:00 | Athletic Bilbao v Villarreal | W | 0-3 |
| Spanien - La Liga | 2018/09/23 14:15 | Villarreal v Valencia | D | 0-0 |
| UEFA Europa League | 2018/09/20 16:55 | Villarreal v Rangers | D | 2-2 |
| Spanien - La Liga | 2018/09/16 10:00 | Leganes v Villarreal | W | 0-1 |
| Spanien - La Liga | 2018/08/31 20:00 | Villarreal v Girona | L | 0-1 |
| Spanien - La Liga | 2018/08/26 20:15 | Sevilla v Villarreal | D | 0-0 |
| Spanien - La Liga | 2018/08/18 18:15 | Villarreal v Real Sociedad | L | 1-2 |