Stadium: Justin F. Coressel Stadium Round: 1
| NCAAF | 2022/10/08 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 55-35 |
| NCAAF | 2021/10/23 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | W | 14-13 |
| NCAAF | 2019/10/05 17:30 | Mount St. Joseph Lions v Defiance Yellow Jackets | L | 59-6 |
| NCAAF | 2018/10/20 17:30 | Defiance Yellow Jackets v Mount St. Joseph Lions | L | 0-20 |
| NCAAF | 2023/09/30 17:30 | Hanover Panthers v Defiance Yellow Jackets | W | 21-27 |
| NCAAF | 2023/09/16 17:00 | Kalamazoo Hornets v Defiance Yellow Jackets | L | 42-35 |
| NCAAF | 2023/09/09 17:00 | Adrian Bulldogs v Defiance Yellow Jackets | W | 17-34 |
| NCAAF | 2023/09/02 17:30 | Defiance Yellow Jackets v Mount Union | L | 6-45 |
| NCAAF | 2022/11/12 18:30 | Bluffton Beavers v Defiance Yellow Jackets | W | 14-17 |
| NCAAF | 2022/11/05 17:30 | Defiance Yellow Jackets v Manchester Spartans | W | 24-21 |
| NCAAF | 2022/10/29 17:30 | Rose Hulman Engineers v Defiance Yellow Jackets | L | 76-35 |
| NCAAF | 2022/10/22 17:30 | Defiance Yellow Jackets v Anderson Ravens | W | 32-22 |
| NCAAF | 2023/09/30 17:30 | Mount St. Joseph Lions v Manchester Spartans | W | 69-14 |
| NCAAF | 2023/09/16 17:00 | Hope Flying Dutchmen v Mount St. Joseph Lions | L | 40-35 |
| NCAAF | 2023/09/09 16:00 | Mount St. Joseph Lions v Hiram Terriers | W | 62-21 |
| NCAAF | 2023/09/02 17:30 | Baldwin Wallace Yellow Jackets v Mount St. Joseph Lions | W | 33-46 |
| NCAAF | 2022/11/19 17:00 | Alma College Scots v Mount St. Joseph Lions | L | 41-21 |
| NCAAF | 2022/11/12 18:30 | Mount St. Joseph Lions v Rose Hulman Engineers | W | 40-31 |
| NCAAF | 2022/11/05 17:30 | Franklin College Grizzlies v Mount St. Joseph Lions | W | 20-27 |
| NCAAF | 2022/10/29 17:30 | Mount St. Joseph Lions v Bluffton Beavers | W | 70-21 |