Stadium: Mississippi Veterans Memorial Stadium Round: 1
Home Manager: Deion Sanders Away Manager: Eric Dooley
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | L | 0-35 |
| NCAAF | 2021/11/14 00:00 | Jackson State v Southern | L | 21-17 |
| NCAAF | 2021/04/03 21:00 | Southern v Jackson State | W | 34-14 |
| NCAAF | 2019/11/16 20:00 | Southern v Jackson State | W | 40-34 |
| NCAAF | 2018/10/27 23:00 | Southern v Jackson State | W | 41-7 |
| NCAAF | 2017/10/21 23:00 | Jackson State v Southern | W | 17-35 |
| NCAAF | 2022/11/26 19:00 | Grambling State v Southern | W | 17-34 |
| NCAAF | 2022/11/12 20:00 | Southern v Mississippi Valley State | W | 27-7 |
| NCAAF | 2022/11/05 22:00 | Southern v Florida A&M | L | 16-30 |
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | L | 0-35 |
| NCAAF | 2022/10/22 21:00 | Southern v Lynchburg Dragons | W | 51-7 |
| NCAAF | 2022/10/15 23:00 | Alcorn State v Southern | W | 17-21 |
| NCAAF | 2022/10/08 21:00 | Southern v Prairie View | W | 45-13 |
| NCAAF | 2022/10/01 23:00 | Arkansas Pine Bluff v Southern | W | 3-59 |
| NCAAF | 2022/11/19 20:00 | Jackson State v Alcorn State | W | 24-13 |
| NCAAF | 2022/11/12 22:00 | Alabama v Jackson State | W | 13-27 |
| NCAAF | 2022/11/05 23:00 | Jackson State v Texas Southern Tigers | W | 41-14 |
| NCAAF | 2022/10/29 18:00 | Southern v Jackson State | W | 0-35 |
| NCAAF | 2022/10/22 19:00 | Campbell v Jackson State | W | 14-22 |
| NCAAF | 2022/10/15 20:00 | Jackson State v Bethune Cookman | W | 48-8 |
| NCAAF | 2022/10/08 19:00 | Jackson State v Alabama State | W | 26-12 |
| NCAAF | 2022/09/24 18:00 | Mississippi Valley State v Jackson State | W | 7-49 |