Stadium: Hancock Stadium Round: 1
Home Manager: Brock Spack Away Manager: Nick Hill
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2019/10/12 23:00 | Illinois State v SO Illinois | L | 21-7 |
| NCAAF | 2018/10/13 19:00 | SO Illinois v Illinois State | L | 3-51 |
| NCAAF | 2017/10/14 19:00 | SO Illinois v Illinois State | W | 42-7 |
| NCAAF | 2022/09/24 19:00 | North Dakota v SO Illinois | W | 17-34 |
| NCAAF | 2022/09/17 16:00 | SO Illinois v Northwestern | W | 31-24 |
| NCAAF | 2022/09/10 23:00 | SE Missouri St v SO Illinois | L | 34-31 |
| NCAAF | 2022/09/03 23:00 | SO Illinois v Incarnate Word | L | 29-64 |
| NCAAF | 2021/12/04 20:30 | SO Illinois v North Dakota State | L | 7-38 |
| NCAAF | 2021/11/27 23:00 | SO Illinois v South Dakota | W | 22-10 |
| NCAAF | 2021/11/20 18:00 | Youngstown State v SO Illinois | L | 35-18 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Indiana State | W | 47-21 |
| NCAAF | 2022/09/17 23:30 | Eastern Illinois v Illinois State | W | 7-35 |
| NCAAF | 2022/09/10 23:30 | Valparaiso v Illinois State | W | 21-28 |
| NCAAF | 2022/09/03 23:00 | Illinois State v Wisconsin | L | 0-38 |
| NCAAF | 2021/11/20 18:00 | Indiana State v Illinois State | L | 15-10 |
| NCAAF | 2021/11/13 20:00 | Illinois State v North Dakota | L | 7-14 |
| NCAAF | 2021/11/06 17:00 | Northern Iowa v Illinois State | W | 10-17 |
| NCAAF | 2021/10/30 20:00 | Illinois State v Western Illinois | L | 31-38 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | W | 20-14 |