Stadium: Cancha Raul Viver Round: 19 Ground: Clay
| Challenger Guayaquil | 2021/10/31 16:00 | Nicolas Alvarez v Federico Zeballos | 6-1,6-0 |
| Challenger Lima | 2021/10/26 00:40 | Nicolas Kicker v Nicolas Alvarez | 4-6,7-6,6-2 |
| Challenger Buenos Aires | 2021/10/18 21:00 | Nicolas Kicker v Nicolas Alvarez | 6-3,2-6,6-3 |
| Challenger Santiago | 2021/10/12 14:00 | Nicolas Alvarez v Sebastian Baez | 5-7,3-6 |
| Challenger Santiago | 2021/10/11 16:50 | Lucas Catarina v Nicolas Alvarez | 6-1,3-6,4-6 |
| Challenger Santiago - Kval | 2021/10/10 14:00 | Nicolas Bruna v Nicolas Alvarez | 1-6,0-6 |
| Challenger Santiago | 2021/10/05 19:50 | Nicolas Alvarez v Camilo Ugo Carabelli | 5-7,1-6 |
| Challenger Santiago | 2021/10/04 16:30 | Nicolas Alvarez v Carlos Gomez-Herrera | 6-3,1-6,6-4 |
| Challenger Guayaquil | 2021/10/31 18:30 | Nicolas Barrientos v Alejandro Gomez | 7-6,6-4 |
| Challenger Bogota | 2021/10/23 15:00 | Gerald Melzer v Nicolas Barrientos | 6-2,6-7,6-1 |
| Challenger Bogota | 2021/10/22 15:00 | Nicolas Barrientos v Oriol Roca Batalla | 6-3,7-5 |
| Challenger Bogota | 2021/10/21 15:00 | Enzo Couacaud v Nicolas Barrientos | 3-6,4-6 |
| Challenger Bogota | 2021/10/19 19:10 | Nicolas Barrientos v Juan Sebastian Gomez | 2-6,6-2,6-4 |
| Challenger Bogota | 2021/10/18 15:00 | Alejandro H Franco v Nicolas Barrientos | 3-6,3-6 |
| Challenger Bogota | 2021/10/17 19:00 | Johan A Rodriguez Rodriguez v Nicolas Barrientos | 5-7,2-6 |
| Challenger Santiago - Kval | 2021/10/10 15:45 | Lucas Catarina v Nicolas Barrientos | 6-4,7-5 |