Stadium: Alexander Durley Stadium Round: 1
Home Manager: Clarence McKinney Away Manager:
| NCAAF | 2021/09/25 22:30 | Texas Southern Tigers v Rice | L | 34-48 |
| NCAAF | 2021/09/11 23:00 | Texas Southern Tigers v Baylor | L | 7-66 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | L | 40-17 |
| NCAAF | 2021/03/21 00:30 | Southern v Texas Southern Tigers | L | 51-23 |
| NCAAF | 2021/03/07 01:00 | Texas Southern Tigers v Prairie View | L | 19-20 |
| NCAAF | 2019/11/23 21:00 | Texas Southern Tigers v Arkansas Pine Bluff | L | 13-45 |
| NCAAF | 2019/11/09 20:00 | Alabama State v Texas Southern Tigers | L | 27-21 |
| NCAAF | 2019/11/02 19:00 | Texas Southern Tigers v Grambling State | L | 20-55 |