[2] STL Blues 2-4 DET Red Wings [4] 2021-11-25 00:30
Stadium: Little Caesars Arena
Home Manager: Jeff Blashill Away Manager: Craig Berube
Head to Head
| NHL | 2019/10/27 21:00 | STL Blues v DET Red Wings | W | 5-4 |
| NHL Pre-Season | 2019/09/26 23:00 | STL Blues v DET Red Wings | L | 1-4 |
| NHL | 2019/03/22 00:00 | DET Red Wings v STL Blues | W | 2-5 |
| NHL | 2018/11/29 00:00 | STL Blues v DET Red Wings | L | 3-4 |
| NHL | 2018/03/01 01:00 | DET Red Wings v STL Blues | W | 1-2 |
| NHL | 2017/12/09 18:00 | STL Blues v DET Red Wings | W | 6-1 |
| NHL | 2017/02/16 01:00 | STL Blues v DET Red Wings | W | 2-0 |
| NHL | 2016/10/28 00:00 | DET Red Wings v STL Blues | L | 2-1 |
Home History
| NHL | 2021/11/23 01:00 | VGS Golden Knights v STL Blues | W | 2-5 |
| NHL | 2021/11/21 01:00 | STL Blues v DAL Stars | L | 1-4 |
| NHL | 2021/11/19 01:00 | SJ Sharks v STL Blues | W | 1-4 |
| NHL | 2021/11/17 01:00 | ARZ Coyotes v STL Blues | L | 3-2 |
| NHL | 2021/11/15 00:00 | EDM Oilers v STL Blues | L | 5-4 |
| NHL | 2021/11/14 00:30 | STL Blues v CAR Hurricanes | L | 2-3 |
| NHL | 2021/11/12 01:00 | NAS Predators v STL Blues | L | 4-3 |
| NHL | 2021/11/10 01:00 | STL Blues v WIN Jets | W | 3-2 |
Away History
| NHL | 2021/11/21 01:00 | DET Red Wings v ARZ Coyotes | L | 1-2 |
| NHL | 2021/11/19 03:00 | DET Red Wings v VGS Golden Knights | L | 2-5 |
| NHL | 2021/11/17 01:30 | DET Red Wings v DAL Stars | L | 2-5 |
| NHL | 2021/11/16 00:00 | DET Red Wings v CLB Blue Jackets | L | 3-5 |
| NHL | 2021/11/14 00:00 | MON Canadiens v DET Red Wings | W | 2-3 |
| NHL | 2021/11/12 00:30 | WAS Capitals v DET Red Wings | L | 2-0 |
| NHL | 2021/11/10 00:30 | EDM Oilers v DET Red Wings | W | 2-4 |
| NHL | 2021/11/07 23:00 | VGS Golden Knights v DET Red Wings | W | 2-5 |