[6] BUF Sabres 2-1 PIT Penguins [13] 2021-11-17 00:00
Stadium: PPG Paints Arena
Home Manager: Mike Sullivan Away Manager: Don Granato
Head to Head
| NHL Pre-Season | 2021/10/05 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2021/10/01 23:00 | PIT Penguins v BUF Sabres | L | 2-1 |
| NHL | 2021/05/08 19:00 | BUF Sabres v PIT Penguins | L | 0-1 |
| NHL | 2021/05/06 23:00 | BUF Sabres v PIT Penguins | L | 4-8 |
| NHL | 2021/04/18 19:00 | PIT Penguins v BUF Sabres | W | 2-4 |
| NHL | 2021/04/17 19:00 | PIT Penguins v BUF Sabres | L | 3-2 |
| NHL | 2021/03/25 23:00 | BUF Sabres v PIT Penguins | L | 0-4 |
| NHL | 2021/03/25 00:00 | BUF Sabres v PIT Penguins | L | 2-5 |
Home History
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2021/11/09 00:00 | BUF Sabres v WAS Capitals | L | 3-5 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL | 2021/11/05 02:00 | BUF Sabres v SEA Kraken | L | 2-5 |
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | L | 3-5 |
| NHL | 2021/10/31 20:00 | BUF Sabres v LA Kings | L | 2-3 |
| NHL | 2021/10/29 02:00 | BUF Sabres v ANA Ducks | W | 4-3 |
Away History
| NHL | 2021/11/15 00:00 | PIT Penguins v WAS Capitals | L | 1-6 |
| NHL | 2021/11/14 00:00 | PIT Penguins v OTT Senators | L | 3-6 |
| NHL | 2021/11/12 00:00 | FLA Panthers v PIT Penguins | W | 2-3 |
| NHL | 2021/11/10 01:30 | PIT Penguins v CHI Blackhawks | L | 2-3 |
| NHL | 2021/11/06 23:00 | MIN Wild v PIT Penguins | L | 5-4 |
| NHL | 2021/11/04 23:00 | PHI Flyers v PIT Penguins | W | 2-3 |
| NHL | 2021/10/30 23:00 | NJ Devils v PIT Penguins | L | 4-2 |
| NHL | 2021/10/28 23:00 | CAL Flames v PIT Penguins | L | 4-0 |