[60] Lorenzo Musetti 6-7,5-7,4-6 Reilly Opelka [24] 2021-09-02 16:00
Stadium: Court 17 Round: 24 Ground: Hardcourt outdoor
Home History
| US Open | 2021/08/31 15:00 | Lorenzo Musetti v Emilio Nava | 6-7,6-4,6-1,6-3 |
| ATP Winston-Salem | 2021/08/23 19:00 | Federico Coria v Lorenzo Musetti | 6-4,4-6,6-4 |
| ATP Cincinnati | 2021/08/14 14:00 | Lorenzo Musetti v Kevin Anderson | 3-6,3-6 |
| OS 2020 - Herrar | 2021/07/24 02:00 | Lorenzo Musetti v John Millman | 3-6,4-6 |
| ATP Båstad | 2021/07/13 15:50 | Henri Laaksonen v Lorenzo Musetti | 6-2,3-6,6-4 |
| Wimbledon | 2021/06/29 16:50 | Hubert Hurkacz v Lorenzo Musetti | 6-4,7-6,6-1 |
| Franska öppna | 2021/06/05 09:00 | Marco Cecchinato v Lorenzo Musetti | 6-3,4-6,3-6,6-3,3-6 |
| Franska öppna | 2021/06/03 10:55 | Yoshihito Nishioka v Lorenzo Musetti | 5-7,3-6,2-6 |
Away History
| US Open | 2021/08/31 15:00 | Soonwoo Kwon v Reilly Opelka | 6-7,4-6,4-6 |
| ATP Cincinnati | 2021/08/18 17:25 | Casper Ruud v Reilly Opelka | 6-7,6-0,7-6 |
| ATP Cincinnati | 2021/08/17 18:40 | Reilly Opelka v Corentin Moutet | 7-6,4-6,6-4 |
| ATP Toronto | 2021/08/15 20:00 | Daniil Medvedev v Reilly Opelka | 6-4,6-3 |
| ATP Toronto | 2021/08/14 19:00 | Stefanos Tsitsipas v Reilly Opelka | 7-6,6-7,4-6 |
| ATP Toronto | 2021/08/13 17:30 | Roberto Bautista-Agut v Reilly Opelka | 3-6,6-7 |
| ATP Toronto | 2021/08/12 18:30 | Reilly Opelka v Lloyd Harris | 4-6,7-6,7-6 |
| ATP Toronto | 2021/08/11 02:35 | Grigor Dimitrov v Reilly Opelka | 3-6,4-6 |