Stadium: Mississippi Veterans Memorial Stadium Round: 1
Home Manager: Deion Sanders Away Manager: Clarence McKinney
| NCAAF | 2021/10/30 19:00 | Arkansas Pine Bluff v Texas Southern Tigers | W | 17-59 |
| NCAAF | 2021/10/24 00:00 | Alcorn State v Texas Southern Tigers | L | 44-27 |
| NCAAF | 2021/10/16 19:00 | Texas Southern Tigers v Grambling State | L | 20-34 |
| NCAAF | 2021/10/09 21:00 | Southern v Texas Southern Tigers | W | 31-35 |
| NCAAF | 2021/10/02 19:00 | Texas Southern Tigers v North American Stallions | W | 69-0 |
| NCAAF | 2021/09/25 22:30 | Texas Southern Tigers v Rice | L | 34-48 |
| NCAAF | 2021/09/11 23:00 | Texas Southern Tigers v Baylor | L | 7-66 |
| NCAAF | 2021/09/05 00:00 | Prairie View v Texas Southern Tigers | L | 40-17 |
| NCAAF | 2021/10/30 20:00 | Jackson State v Mississippi Valley State | W | 28-19 |
| NCAAF | 2021/10/23 18:00 | Bethune Cookman v Jackson State | W | 12-42 |
| NCAAF | 2021/10/16 19:00 | Alabama State v Jackson State | W | 7-28 |
| NCAAF | 2021/10/09 19:00 | Jackson State v Alabama | W | 61-15 |
| NCAAF | 2021/09/25 19:00 | Jackson State v Delta State | W | 24-17 |
| NCAAF | 2021/09/19 00:00 | Jackson State v UL Monroe | L | 7-12 |
| NCAAF | 2021/09/11 23:00 | Jackson State v Tennessee State | W | 38-16 |
| NCAAF | 2021/09/05 19:00 | Jackson State v Florida A&M | W | 7-6 |