[64] Maryland 21-40 Michigan State [14] 2021-11-13 21:00
Stadium: Spartan Stadium Round: 1
Home Manager: Mel Tucker Away Manager: Mike Locksley
Head to Head
| NCAAF | 2019/11/30 20:30 | Maryland v Michigan State | L | 16-19 |
| NCAAF | 2018/11/03 16:00 | Michigan State v Maryland | L | 24-3 |
| NCAAF | 2017/11/18 21:00 | Maryland v Michigan State | L | 7-17 |
| NCAAF | 2016/10/22 23:30 | Michigan State v Maryland | W | 17-28 |
| NCAAF | 2015/11/14 17:00 | Michigan State v Maryland | L | 24-7 |
| NCAAF | 2014/11/16 01:00 | Maryland v Michigan State | L | 15-37 |
Home History
| NCAAF | 2021/11/06 19:30 | Penn State v Maryland | L | 31-14 |
| NCAAF | 2021/10/30 16:00 | Indiana v Maryland | W | 35-38 |
| NCAAF | 2021/10/23 19:30 | Maryland v Minnesota | L | 16-34 |
| NCAAF | 2021/10/09 16:00 | Maryland v Ohio State | L | 17-66 |
| NCAAF | 2021/10/02 00:00 | Iowa v Maryland | L | 51-14 |
| NCAAF | 2021/09/25 19:30 | Kent State v Maryland | W | 16-37 |
| NCAAF | 2021/09/18 01:00 | Maryland v Illinois | W | 20-17 |
| NCAAF | 2021/09/11 23:30 | Howard v Maryland | W | 0-62 |
Away History
| NCAAF | 2021/11/06 19:30 | Michigan State v Purdue | L | 29-40 |
| NCAAF | 2021/10/30 16:00 | Michigan v Michigan State | W | 33-37 |
| NCAAF | 2021/10/16 16:00 | Michigan State v Indiana | W | 20-15 |
| NCAAF | 2021/10/09 16:00 | Michigan State v Rutgers | W | 31-13 |
| NCAAF | 2021/10/02 23:30 | Western Kentucky v Michigan State | W | 31-48 |
| NCAAF | 2021/09/25 23:00 | Nebraska v Michigan State | W | 20-23 |
| NCAAF | 2021/09/18 16:00 | Michigan State v Miami Florida | W | 38-17 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | W | 14-42 |