Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Doug Phillips
| NCAAF | 2021/03/06 17:00 | SO Illinois v Youngstown State | L | 30-22 |
| NCAAF | 2019/10/19 19:00 | Youngstown State v SO Illinois | L | 10-35 |
| NCAAF | 2018/10/06 22:00 | SO Illinois v Youngstown State | W | 14-17 |
| NCAAF | 2017/11/11 19:00 | SO Illinois v Youngstown State | W | 20-28 |
| NCAAF | 2021/11/13 17:00 | North Dakota State v Youngstown State | L | 49-17 |
| NCAAF | 2021/11/06 17:00 | Youngstown State v North Dakota | L | 21-24 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | L | 47-16 |
| NCAAF | 2021/10/23 17:00 | Youngstown State v Indiana State | L | 17-28 |
| NCAAF | 2021/10/09 18:00 | Missouri St v Youngstown State | W | 33-41 |
| NCAAF | 2021/10/02 21:00 | Youngstown State v Northern Iowa | L | 7-34 |
| NCAAF | 2021/09/25 22:00 | Western Illinois v Youngstown State | L | 38-35 |
| NCAAF | 2021/09/11 16:00 | Youngstown State v Michigan State | L | 14-42 |
| NCAAF | 2021/11/13 18:00 | SO Illinois v Indiana State | W | 47-21 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | L | 38-28 |
| NCAAF | 2021/10/30 21:00 | SO Illinois v Northern Iowa | L | 16-23 |
| NCAAF | 2021/10/16 19:00 | North Dakota v SO Illinois | W | 28-31 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | W | 42-41 |
| NCAAF | 2021/10/02 20:00 | SO Illinois v Western Illinois | W | 31-30 |
| NCAAF | 2021/09/25 19:00 | Illinois State v SO Illinois | W | 17-35 |
| NCAAF | 2021/09/18 23:00 | Dayton v SO Illinois | W | 3-55 |