[13] Crystal Palace 2-2 Southampton [15] 2021-12-15 19:30
Stadium: Selhurst Park Round: 17
Referee: Simon Hooper Home Manager: Patrick Vieira Away Manager: Ralph Hasenhuttl
Head to Head
| England - Premier League | 2021/05/11 19:15 | Southampton v Crystal Palace | L | 3-1 |
| England - Premier League | 2020/09/12 14:00 | Crystal Palace v Southampton | W | 1-0 |
| England - Premier League | 2020/01/21 19:30 | Crystal Palace v Southampton | L | 0-2 |
| England - Premier League | 2019/12/28 15:00 | Southampton v Crystal Palace | D | 1-1 |
| England - Premier League | 2019/01/30 19:45 | Southampton v Crystal Palace | D | 1-1 |
| England - Premier League | 2018/09/01 14:00 | Crystal Palace v Southampton | L | 0-2 |
| England - Premier League | 2018/01/02 19:45 | Southampton v Crystal Palace | W | 1-2 |
| England - Premier League | 2017/09/16 11:30 | Crystal Palace v Southampton | L | 0-1 |
Home History
| England - Premier League | 2021/12/12 16:30 | Crystal Palace v Everton | W | 3-1 |
| England - Premier League | 2021/12/05 14:00 | Man Utd v Crystal Palace | L | 1-0 |
| England - Premier League | 2021/11/30 20:15 | Leeds v Crystal Palace | L | 1-0 |
| England - Premier League | 2021/11/27 15:00 | Crystal Palace v Aston Villa | L | 1-2 |
| England - Premier League | 2021/11/20 15:00 | Burnley v Crystal Palace | D | 3-3 |
| England - Premier League | 2021/11/06 15:00 | Crystal Palace v Wolverhampton | W | 2-0 |
| England - Premier League | 2021/10/30 14:00 | Man City v Crystal Palace | W | 0-2 |
| England - Premier League | 2021/10/23 14:00 | Crystal Palace v Newcastle | D | 1-1 |
Away History
| England - Premier League | 2021/12/11 15:00 | Arsenal v Southampton | L | 3-0 |
| England - Premier League | 2021/12/04 15:00 | Southampton v Brighton | D | 1-1 |
| England - Premier League | 2021/12/01 19:30 | Southampton v Leicester | D | 2-2 |
| England - Premier League | 2021/11/27 15:00 | Liverpool v Southampton | L | 4-0 |
| England - Premier League | 2021/11/20 15:00 | Norwich v Southampton | L | 2-1 |
| England - Premier League | 2021/11/05 20:00 | Southampton v Aston Villa | W | 1-0 |
| England - Premier League | 2021/10/30 14:00 | Watford v Southampton | W | 0-1 |
| England - Ligacupen | 2021/10/26 18:45 | Chelsea v Southampton | L | 5-4 |