Stadium: O'Brien Stadium Round: 1
Home Manager: Adam Cushing Away Manager: Mark Elder
| NCAAF | 2018/10/27 17:00 | Eastern Kentucky v Eastern Illinois | W | 31-23 |
| NCAAF | 2017/11/04 18:00 | Eastern Illinois v Eastern Kentucky | L | 23-20 |
| NCAAF | 2019/10/19 19:00 | Eastern Kentucky v Murray State | W | 34-27 |
| NCAAF | 2019/10/05 19:00 | Tennessee Martin v Eastern Kentucky | L | 38-28 |
| NCAAF | 2019/09/28 22:00 | Tennessee State v Eastern Kentucky | W | 16-42 |
| NCAAF | 2019/09/21 17:00 | Eastern Kentucky v Presbyterian | W | 35-10 |
| NCAAF | 2019/09/14 17:00 | Eastern Kentucky v Indiana State | L | 7-19 |
| NCAAF | 2019/09/07 23:00 | Eastern Kentucky v Louisville | L | 0-42 |
| NCAAF | 2019/08/29 23:00 | Valparaiso v Eastern Kentucky | W | 7-53 |
| NCAAF FCS | 2018/11/17 19:30 | Eastern Kentucky v Tennessee Tech | W | 37-6 |
| NCAAF | 2019/10/19 19:00 | Eastern Illinois v Tennessee Martin | L | 18-27 |
| NCAAF | 2019/10/12 17:00 | Jacksonville State v Eastern Illinois | L | 28-20 |
| NCAAF | 2019/10/05 18:00 | Eastern Illinois v Murray State | L | 17-24 |
| NCAAF | 2019/09/28 21:00 | Tennessee Tech v Eastern Illinois | L | 40-29 |
| NCAAF | 2019/09/21 17:00 | Eastern Illinois v Indiana State | L | 6-16 |
| NCAAF | 2019/09/14 19:00 | Illinois State v Eastern Illinois | L | 21-3 |
| NCAAF | 2019/09/07 19:30 | Eastern Illinois v Indiana | L | 0-52 |
| NCAAF | 2019/08/29 23:00 | Eastern Illinois v Tennessee Chattanooga | L | 10-24 |