[13] Santos Laguna 2-1 Queretaro [17] 2019-04-21 23:06
Stadium: Estadio TSM Corona Round: 15
Referee: Francisco Chacon Gutierrez Home Manager: Guillermo Almada Away Manager: Victor Vucetich
Head to Head
| Mexiko - Liga MX | 2018/11/04 22:00 | Queretaro v Santos Laguna | L | 2-1 |
| Mexiko - Liga MX | 2018/04/08 23:00 | Santos Laguna v Queretaro | W | 3-0 |
| Mexiko - Cup | 2018/03/14 03:15 | Santos Laguna v Queretaro | W | 1-0 |
| Mexiko - Liga MX | 2017/10/21 22:00 | Queretaro v Santos Laguna | W | 1-2 |
| Mexiko - Liga MX | 2017/04/02 23:00 | Santos Laguna v Queretaro | W | 1-0 |
| Mexiko - Liga MX | 2016/10/01 22:00 | Queretaro v Santos Laguna | D | 1-1 |
| Mexiko - Liga MX | 2016/01/30 03:30 | Santos Laguna v Queretaro | W | 2-0 |
| Mexiko - Liga MX | 2015/08/12 01:30 | Queretaro v Santos Laguna | W | 1-2 |
Home History
| Mexiko - Liga MX | 2019/04/15 01:30 | Monterrey v Santos Laguna | L | 4-0 |
| CONCACAF Champions Cup | 2019/04/11 00:00 | Santos Laguna v Tigres UANL | W | 3-2 |
| Mexiko - Liga MX | 2019/04/07 23:06 | Santos Laguna v Pachuca | D | 0-0 |
| CONCACAF Champions Cup | 2019/04/04 02:00 | Tigres UANL v Santos Laguna | L | 3-0 |
| Mexiko - Liga MX | 2019/03/30 03:00 | Atlas v Santos Laguna | L | 1-0 |
| Mexiko - Liga MX | 2019/03/18 00:06 | Santos Laguna v Necaxa | L | 1-2 |
| CONCACAF Champions Cup | 2019/03/13 01:00 | Santos Laguna v New York Red Bulls | W | 4-2 |
| Mexiko - Liga MX | 2019/03/09 01:00 | Veracruz v Santos Laguna | D | 2-2 |
Away History
| Mexiko - Liga MX | 2019/04/13 22:00 | Queretaro v Toluca | D | 0-0 |
| Mexiko - Liga MX | 2019/04/06 23:06 | Cruz Azul v Queretaro | L | 3-0 |
| Mexiko - Liga MX | 2019/03/30 23:00 | Queretaro v Tijuana | W | 1-0 |
| Mexiko - Liga MX | 2019/03/17 03:00 | Tigres UANL v Queretaro | L | 4-1 |
| Mexiko - Liga MX | 2019/03/10 03:00 | Queretaro v Chivas Guadalajara | D | 0-0 |
| Mexiko - Liga MX | 2019/03/05 02:00 | Puebla v Queretaro | L | 1-0 |
| Mexiko - Liga MX | 2019/02/23 23:00 | Queretaro v Atletico Morelia | W | 3-0 |
| Mexiko - Cup | 2019/02/21 03:00 | Dorados v Queretaro | D | 1-1 |